Evidence supporting the use of: Perilla
For the health condition: Nephritis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Perilla (Perilla frutescens), known for its culinary and medicinal uses in East Asian countries, has a history of use in traditional Chinese medicine (TCM). It is most commonly utilized for its purported anti-inflammatory, anti-allergic, and antioxidant properties. In TCM, perilla leaves (Zisu Ye) are typically used to "disperse cold," "regulate qi," and "alleviate seafood poisoning," but not specifically for nephritis. However, some multi-herb formulations for kidney-related conditions may include perilla as a component, presumably for its general anti-inflammatory or immune-modulating effects rather than direct kidney action. Scientific studies investigating perilla’s effects on nephritis are minimal and largely limited to preclinical animal models or in vitro research. Some studies suggest perilla oil may attenuate inflammation and oxidative stress, which could theoretically benefit kidney health, but direct evidence for efficacy in nephritis is lacking. Therefore, the use of perilla for nephritis is primarily justified by tradition rather than robust scientific validation. The overall quality and quantity of evidence supporting its use for nephritis is low, meriting a rating of 1 out of 5.

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