Animal tissue, particularly nerve grafts or extracts from animal sources, has been explored and sometimes used in the support or treatment of nerve damage. The scientific rationale stems from the structural and biochemical similarities between animal and human tissues, which can potentially facilitate nerve regeneration. For example, decellularized nerve allografts or xenografts (from animals) have been investigated as conduits or scaffolds to guide axonal growth in peripheral nerve injuries. Some commercial nerve repair products are derived from animal tissues (e.g., porcine small intestinal submucosa or bovine collagen conduits).

However, the evidence supporting the efficacy of animal tissue-derived products in humans is limited and mostly based on preclinical studies, small clinical trials, or case reports. While some studies indicate that these materials can support nerve regeneration and functional recovery, results are variable and often not superior to autologous nerve grafts (nerve tissue taken from the patient’s own body), which remain the gold standard. There are also concerns regarding immunogenicity, disease transmission, and ethical considerations. Major guidelines consider the use of animal tissue products experimental, and their use is not routine or universally accepted for nerve repair.

In summary, there is a scientific basis for the use of animal tissue in nerve repair, but the evidence base is still developing, and clinical adoption is cautious. The evidence strength is rated as 2/5, reflecting preliminary but not definitive support.