Evidence supporting the use of: Apigenin
For the health condition: Nerve Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin is a naturally occurring flavonoid found in various plants, including parsley, chamomile, and celery. Its potential neuroprotective effects have been explored in several preclinical (mostly animal and in vitro) studies. The scientific rationale for using apigenin to support or treat nerve damage centers on its anti-inflammatory, antioxidant, and anti-apoptotic properties. Research has shown that apigenin can reduce oxidative stress and inflammation, both of which contribute to nerve injury and degeneration. In rodent models of neurodegenerative diseases and nerve injury, apigenin has demonstrated the ability to inhibit the production of pro-inflammatory cytokines, reduce neuronal cell death, and promote neuronal survival and regeneration. However, most of the evidence to date comes from laboratory and animal studies. For example, studies have shown that apigenin can attenuate neural damage in models of spinal cord injury and peripheral nerve injury, as well as provide some protection in models of Alzheimer’s disease and other neurodegenerative conditions. Despite these promising findings, there is a lack of robust clinical trials in humans that specifically assess apigenin’s efficacy for nerve damage. In summary, while there is scientific interest and preclinical evidence suggesting apigenin may help protect nerves or support nerve repair, current evidence in humans is limited. More research, especially well-designed clinical studies, is necessary to determine its practical therapeutic value for nerve damage.

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