Evidence supporting the use of: Cocarboxylase
For the health condition: Nerve Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cocarboxylase, also known as thiamine pyrophosphate (TPP), is the active coenzyme form of vitamin B1 (thiamine). It plays a crucial role in carbohydrate metabolism and neural function by acting as a cofactor for enzymes involved in the Krebs cycle and neurotransmitter synthesis. Thiamine deficiency is well established as a cause of peripheral neuropathy, particularly in conditions such as beriberi and Wernicke-Korsakoff syndrome. Therefore, administration of thiamine or its active form, cocarboxylase, has been used in the treatment of neuropathies resulting from deficiency states. However, the evidence supporting the use of cocarboxylase specifically for general nerve damage not related to thiamine deficiency is limited. Most clinical guidelines recommend thiamine supplementation in cases of proven or suspected deficiency, but there is insufficient high-quality evidence to support its use in neuropathies from other causes (e.g., diabetic neuropathy, traumatic nerve injury). Some studies suggest potential symptomatic relief in certain neuropathies, but these are often small, non-randomized, or lack rigorous controls. In summary, while there is scientific rationale and some evidence for the use of cocarboxylase in neuropathy due to thiamine deficiency, scientific support for its use in other types of nerve damage is weak. The overall evidence rating is 2 out of 5, reflecting its established role in deficiency-related neuropathy but insufficient data for broader applications.

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Other health conditions supported by cocarboxylase

Diabetes
Fatigue
Heart (weakness)
Nerve Damage
Neuralgia and Neuritis

Products containing cocarboxylase

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