Indian Pipe (Monotropa uniflora), also known as Ghost Pipe, has a history of use in North American indigenous herbal traditions, particularly among some Native American groups. Traditionally, the plant has been used as a nervine—an agent believed to support the nervous system—and as an analgesic for pain relief, including pain associated with nerve damage or neuralgia. Historical ethnobotanical sources cite its use for calming the nerves, treating convulsions, and alleviating various forms of pain, sometimes specifically referencing “nerve pain” or “nervous conditions.”

However, there is a lack of modern scientific research or clinical trials validating the efficacy or safety of Indian Pipe for nerve damage or neuropathy. The plant contains compounds such as monotropin and salicylic acid derivatives, but their pharmacological effects have not been rigorously studied in humans. The available evidence is thus anecdotal and based on traditional usage rather than modern scientific validation. Furthermore, the safety profile of Indian Pipe is not well established, and its use is not recommended without professional supervision.

In summary, Indian Pipe’s use for nerve damage is primarily supported by traditional herbal practices, with very limited evidence from scientific research. Its historical use does not guarantee efficacy or safety for nerve damage in contemporary medical contexts.