Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Specialized pro-resolving mediators (SPMs) are a group of bioactive lipid compounds derived from omega-3 fatty acids, including resolvins, protectins, and maresins. SPMs have been studied for their role in resolving inflammation and promoting tissue repair, which is relevant to nerve damage where chronic inflammation can impede regeneration and recovery. Preclinical studies (in animal models) have shown that SPMs can reduce neuroinflammation, promote nerve regeneration, and decrease neuropathic pain. For example, resolvin D1 and E1 have demonstrated efficacy in reducing pain and inflammation in rodent models of nerve injury. Some studies also suggest that SPMs can modulate glial cell activity and enhance the clearance of cellular debris, further supporting nerve repair processes.

However, the evidence supporting the use of SPMs for nerve damage in humans is currently limited. Most data come from laboratory or animal studies, and robust clinical trials in humans are lacking as of 2024. While the mechanistic rationale is strong and early results are promising, more research is needed to establish safety, efficacy, dosing, and long-term effects in people with nerve damage. Thus, scientific interest is high, but clinical validation remains preliminary, resulting in a moderate evidence score.

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Douglas Laboratories QÜELL® FISH OIL DHA Ultra SPM