Evidence supporting the use of: Thiamin
For the health condition: Nerve Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Thiamin (vitamin B1) is scientifically validated for use in certain types of nerve damage, primarily those associated with thiamin deficiency. Thiamin is an essential cofactor in carbohydrate metabolism and nerve function, and its deficiency can cause neurological disorders such as beriberi and Wernicke-Korsakoff syndrome. Both conditions feature prominent nerve damage, including peripheral neuropathy and central nervous system symptoms. The restoration of normal thiamin levels through supplementation can reverse or halt nerve damage in these contexts, and this is well-documented in both historical and modern clinical literature (NIH).

However, evidence for thiamin supplementation improving nerve damage not caused by deficiency (e.g., diabetic neuropathy, chemotherapy-induced neuropathy) is less robust. Some small studies and clinical trials suggest possible benefit, particularly with benfotiamine (a thiamin derivative) in diabetic neuropathy, but findings are mixed and further research is needed. Thus, while thiamin is a first-line treatment for neuropathy due to deficiency, its role in non-deficiency-related nerve damage is not as strongly established. Overall, scientific evidence supports thiamin’s use for nerve damage linked to deficiency, justifying a high (4/5) evidence rating for these indications.

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Products containing Thiamin

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