Evidence supporting the use of: Transforming growth factor beta
For the health condition: Nerve Damage

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Transforming growth factor beta (TGF-β) is a multifunctional cytokine that plays a significant role in various cellular processes, including cell growth, differentiation, and immune modulation. There is scientific evidence, largely from preclinical studies, that supports the involvement of TGF-β in nerve repair and regeneration. In animal models, TGF-β has been shown to mediate both protective and regenerative processes following nerve injury. It promotes the survival of neurons, modulates inflammatory responses, and stimulates the proliferation and differentiation of Schwann cells, which are essential for peripheral nerve regeneration. TGF-β also contributes to the formation of the extracellular matrix, which is crucial for guiding axonal regrowth. However, the therapeutic application of TGF-β in the treatment of nerve damage is complex. While some studies suggest beneficial effects, others indicate that excessive or prolonged TGF-β activity may lead to fibrosis and scarring, potentially hindering nerve regeneration. Clinical data in humans are limited, and direct therapeutic use of TGF-β for nerve damage remains experimental. Most existing evidence comes from animal studies or in vitro experiments, and there are currently no widely approved TGF-β-based therapies for nerve damage in clinical practice. In summary, scientific research provides a mechanistic rationale for the use of TGF-β in nerve repair, but the evidence is not yet robust or consistent enough for routine clinical application. Ongoing research aims to clarify the therapeutic potential and optimal regulation of TGF-β signaling in nerve injury.

More about Transforming growth factor beta
More about Nerve Damage

Products containing Transforming growth factor beta

We currently have no products on Vitabase that contain this ingredient.