Chloride is an essential electrolyte in the human body, closely involved in the function of the nervous system. Its role is primarily scientific, as documented by physiological and biochemical research rather than traditional herbal or folk medicine uses. Chloride, alongside sodium and potassium, helps maintain the resting membrane potential of neurons and is crucial for the generation and propagation of action potentials—the electrical signals nerves use to communicate. Specifically, chloride ions participate in inhibitory neurotransmission via GABA and glycine receptors, where chloride influx causes hyperpolarization of neurons, preventing excessive firing and contributing to proper nervous system regulation.

Deficiency in chloride (hypochloremia) can disrupt this balance, potentially leading to neurological symptoms such as confusion, seizures, or muscle spasms, though such deficiencies are rare in individuals with normal diets. Most scientific validation comes from physiological studies and clinical observations of electrolyte imbalances rather than interventional trials specifically supplementing chloride for nervous system support. Thus, while chloride is indisputably necessary for proper nervous system function, direct supplementation is typically only warranted in cases of deficiency or certain medical conditions.

In summary, the link between chloride and nervous system health is scientifically established, but the evidence for supplementation beyond correcting deficiencies is moderate, reflecting its foundational but non-therapeutic role.