Evidence supporting the use of: L-carnitine
For the body system: Nerves

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-carnitine is a naturally occurring compound involved in energy metabolism, specifically the transport of long-chain fatty acids into the mitochondria for beta-oxidation. Its role in supporting the nervous system has been explored in both preclinical and clinical settings. Research has shown that acetyl-L-carnitine, a derivative of L-carnitine, can cross the blood-brain barrier and may exert neuroprotective effects by enhancing mitochondrial function, reducing oxidative stress, and promoting the synthesis of acetylcholine, a key neurotransmitter. Clinical studies have found that L-carnitine and acetyl-L-carnitine supplementation may benefit individuals with peripheral neuropathy, particularly in the context of diabetic neuropathy and chemotherapy-induced neuropathy, by reducing pain and improving nerve conduction. However, results are not universally consistent, and effect sizes are generally modest. There is also preliminary evidence suggesting potential cognitive benefits in age-related cognitive decline, likely due to improved neuronal energy metabolism. Overall, the use of L-carnitine for nerve health is scientifically informed, though evidence is moderate and not definitive for all nervous system disorders. Further well-designed, large-scale clinical trials are needed to confirm its efficacy and clarify its mechanisms of action.

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