L-glycine, a non-essential amino acid, plays several important roles in the human body, including as a neurotransmitter in the central nervous system. Scientific studies have shown that glycine acts as an inhibitory neurotransmitter, particularly in the spinal cord, brainstem, and retina. It binds to glycine receptors, producing inhibitory effects that help regulate excitability in the nervous system. This mechanism is foundational for its potential use in supporting the nervous system.

Research suggests that glycine supplementation may improve sleep quality, reduce symptoms of some neuropsychiatric disorders (such as schizophrenia), and provide neuroprotection in certain models of stroke and neurodegeneration. For example, some clinical studies have demonstrated improved sleep latency and quality in individuals taking glycine before bedtime. There is also preliminary evidence that glycine may help modulate cognitive and emotional functions.

However, while these findings are promising, the overall clinical evidence is limited by small sample sizes, short study durations, and a lack of large-scale randomized controlled trials. Thus, while there is a scientific rationale and early evidence supporting glycine's role in nervous system function, more research is needed for definitive conclusions and clinical recommendations.