Purple Monkeyflower (Mimulus spp.) has a history of use in traditional and folk herbalism, particularly within North American Indigenous practices and some modern herbal traditions. Its primary association with the nervous system comes through its use as a Bach Flower Remedy, where it is employed to address emotional states such as fear, anxiety, and shyness. In this context, it is not the physical plant extract but a flower essence—a highly diluted solution believed by proponents to carry the energetic imprint of the flower—that is used. There is little to no robust scientific research validating the efficacy of Purple Monkeyflower or its essence for supporting the physiological nervous system or for treating anxiety or nervous conditions. The evidence supporting its use is therefore rooted in traditional or alternative healing systems rather than clinical trials or pharmacological studies. Although some anecdotal reports suggest benefits, these are not supported by systematic research. As such, Purple Monkeyflower’s use for the nerves is justified by tradition and alternative practices rather than by scientific evidence.