Evidence supporting the use of: Salidroside
For the body system: Nerves

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Salidroside is a bioactive compound found in Rhodiola rosea, a medicinal plant traditionally used in Russia, Scandinavia, and China for its adaptogenic properties. Recent scientific research has begun to elucidate its effects on the nervous system. Preclinical studies in cell and animal models suggest that salidroside exhibits neuroprotective properties, possibly through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. For example, salidroside has been shown to reduce neuronal cell death in models of Parkinson’s and Alzheimer’s diseases, and to protect against glutamate-induced cytotoxicity in vitro. Additionally, some studies indicate it may improve cognitive function and reduce depressive-like behaviors in rodents subjected to chronic stress. Mechanistically, these effects are linked to the regulation of neurotransmitter levels, inhibition of oxidative stress, and modulation of signaling pathways involved in cell survival.

However, while the preclinical evidence is promising, high-quality clinical trials in humans are limited. Most human studies on Rhodiola rosea (rather than isolated salidroside) report improvements in symptoms of stress, fatigue, and mood, but the direct contribution of salidroside remains unclear. Therefore, current use to support the nervous system is based on a growing body of laboratory research with moderate support, but robust clinical validation is lacking.

More about Salidroside
More about Nerves

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Products containing Salidroside

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