Evidence supporting the use of: Licorice root
For the health condition: Nervous Exhaustion

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Licorice root (Glycyrrhiza glabra) has a long history of use in traditional medicine systems, particularly in Traditional Chinese Medicine (TCM) and Ayurveda, where it is considered an adaptogenic herb. In these systems, "nervous exhaustion"—described broadly as fatigue, weakness, and diminished vitality due to stress or prolonged illness—has been addressed with licorice root as a component of restorative formulas. Traditional practitioners believed licorice root could "harmonize" other herbs and strengthen the body's resistance to stress by supporting adrenal function and replenishing depleted energy, often referred to as "qi" or "prana."

From a scientific standpoint, licorice root contains glycyrrhizin and other compounds that may influence the hypothalamic-pituitary-adrenal (HPA) axis and cortisol metabolism, theoretically supporting the body under stress. Some preliminary studies suggest possible adaptogenic or anti-fatigue effects, but these are not robust or directly focused on "nervous exhaustion" as a clinically defined condition. There are no high-quality clinical trials specifically validating its efficacy for this purpose, and most evidence remains anecdotal or extrapolated from general adaptogenic mechanisms.

In summary, the use of licorice root for nervous exhaustion is primarily justified by traditional use, with limited scientific rationale and low-quality supportive data. Caution should be exercised due to potential side effects such as hypertension and hypokalemia with prolonged use.

More about licorice root
More about Nervous Exhaustion

Other health conditions supported by licorice root

Abdominal Pain
Abrasions
Abscesses
Acid Indigestion
Acne
Addictions (general remedies for)
Addictions (tobacco smoking or chewing)
Addison's Disease
Adenitis
Adrenal Fatigue
Afterbirth Pain
Age Spots
Allergies (respiratory)
Amenorrhea
Anal Fistula or Fissure
Anemia
Appetite (deficient)
Asthma
Autoimmune Disorders
Bronchitis
Canker Sores
Chemotherapy (reducing side effects)
Chicken Pox
Cholera
Chronic Obstructive Pulmonary Disorder
Cirrhosis of the Liver
Cold Sores
Colds (antiviral)
Colds (decongestant)
Colds (general)
Colds (prevention)
Colds (with fever)
Colic (adults)
Colic (children)
Colitis
Colon (atonic)
Colon (spastic)
Congestion
Congestion (bronchial)
Congestion (lungs)
Congestion (lymphatic)
Congestion (sinus)
Constipation (adults)
Contagious Diseases
Convalescence
Cough (damp)
Cough (dry)
Cough (general)
Cough (spastic)
Cramps (menstrual)
Crohn's Disease
Croup
Cushing's Disease
Cytomealovirus
Dyspepsia
Eczema
Emphysema
Endometriosis
Enteritis
Epstein Barr Virus
Estrogen (low)
Fatty Liver Disease
Fever
Fibrosis
Gall Bladder (sluggish or removed)
Gall Stones
Gas and Bloating
Gastritis
Gingivitis
Glands (swollen lymph)
Goiter
Gonorrhea
Gout
Grave's Disease
Hair (loss or thinning)
Hair Care (general)
Halitosis
Hangover
Headache (general)
Headache (sinus)
Headache (tension)
Heart (weakness)
Hemorrhoids
Hepatitis
Hernias
Herpes
Hiatal Hernia
Hiccups
Hot Flashes
Hypotension
Hypothyroid
Impetigo
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Infection
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Infection (viral)
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Itching
Itching Ears
Jaundice (adults)
Jock Itch
Kidney Infection
Laryngitis
Leaky Gut Syndrome
Leprosy
Lesions
Leucorrhea
Liver Detoxification
Lungs (fluid in)
Lyme Disease
Lymph Nodes or Glands (swollen)
Malaria
Mastitis
Measles
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Metabolic Syndrome
Mononucleosis
Mood Swings
Morning Sickness
Mumps
Nausea and Vomiting
Nephritis
Nervous Exhaustion
Nervousness
Night Sweating
Nocturnal Emission
Oral Surgery
Ovarian Pain
Overacidity
Pertussis
Pleurisy
PMS (general)
Pneumonia
Poison Ivy or Oak
Rashes and Hives
Rosacea
Sore Throat
Ulcers