The use of pollen, especially bee pollen, as a remedy for "nervous exhaustion" is rooted primarily in traditional and naturopathic medicine rather than in robust scientific evidence. Historically, pollen has been considered a "tonic" in various folk medicine systems, promoted as a general vitality booster and adaptogen. Proponents believed that its rich composition—containing vitamins, minerals, amino acids, and antioxidants—could help restore energy, reduce fatigue, and support the nervous system. Some 20th-century European naturopaths and herbalists recommended pollen for convalescents and those experiencing stress-related fatigue, a condition sometimes labeled as "nervous exhaustion."

However, modern scientific research specifically addressing pollen's effects on nervous exhaustion or related mental fatigue is extremely limited. While a few small studies have examined bee pollen for enhancing general well-being or physical endurance, these studies are often preliminary, lack rigorous design, and do not directly address nervous system support or exhaustion. Most clinical literature focuses on pollen’s nutritional profile or its potential immunomodulatory and antioxidant effects rather than neurological outcomes. As such, current evidence does not substantiate the traditional claims for its efficacy in treating nervous exhaustion, and pollen’s use for this condition remains largely anecdotal and traditional.