Evidence supporting the use of: Rhodiola
For the health condition: Nervous Exhaustion

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rhodiola (Rhodiola rosea) is an adaptogenic herb traditionally used in Eastern Europe and Asia to combat fatigue and enhance resilience to stress. The term "nervous exhaustion" historically refers to symptoms of chronic stress, fatigue, and mental weariness. Scientific interest in rhodiola has grown over the past few decades, with several randomized controlled trials and meta-analyses examining its effects on fatigue, stress, and cognitive performance.

A 2012 systematic review published in Phytomedicine concluded that rhodiola extracts may benefit physical and mental fatigue under stressful conditions, though most studies had methodological limitations (e.g., small sample sizes, lack of blinding). More recent studies, such as a 2017 randomized, double-blind, placebo-controlled trial in Neuropsychiatric Disease and Treatment, found that rhodiola extract improved symptoms of burnout, including emotional exhaustion and fatigue, compared to placebo. The proposed mechanisms involve modulation of neurotransmitters such as serotonin, dopamine, and norepinephrine, as well as reduction of cortisol levels.

While the evidence base is not robust enough for unequivocal endorsement, it is stronger than for many other herbal remedies. Thus, rhodiola's use for "nervous exhaustion" is supported by both tradition and a moderate degree of scientific validation, reflected in a mid-range evidence score.

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