Evidence supporting the use of: Schizandrol A
For the health condition: Nervous Exhaustion

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Schizandrol A, a bioactive compound isolated from the fruit of Schisandra chinensis, has a long history of use in traditional Chinese medicine (TCM) for supporting vitality and resilience to stress—often described as “nervous exhaustion” or “fatigue.” In TCM, Schisandra is considered an adaptogen, thought to boost “Qi” (vital energy) and support the body’s ability to resist physical and mental stressors. Historical texts and modern herbal compendia report its traditional use for symptoms that align with nervous exhaustion, such as fatigue, weakness, and irritability.

Modern scientific studies on Schizandrol A specifically are limited. Most research focuses on general extracts of Schisandra chinensis, suggesting possible neuroprotective, adaptogenic, and anti-fatigue effects in animal models, such as improved endurance and reduced markers of stress. However, robust clinical trials in humans are lacking, and the term "nervous exhaustion" is not a standard medical diagnosis, making direct evidence scant. Therefore, the use of Schizandrol A for this purpose is primarily justified by traditional use, with low-level scientific support from preclinical studies rather than rigorous human trials.

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