Evidence supporting the use of: Vitamin B1 (Sulbutiamine)
For the health condition: Nervous Exhaustion

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulbutiamine is a synthetic derivative of vitamin B1 (thiamine) that is sometimes used to address symptoms described as "nervous exhaustion," which can include fatigue, lack of energy, and mental burnout. The rationale for its use stems from its ability to cross the blood-brain barrier more effectively than standard thiamine, potentially enhancing central nervous system thiamine levels.

Some small-scale clinical studies and user reports suggest sulbutiamine may improve asthenia (physical and mental fatigue), particularly in the context of infectious diseases or chronic fatigue syndromes. For example, clinical trials in the 1970s and 1980s in France reported improvements in fatigue with sulbutiamine compared to placebo. However, these studies were limited by small sample sizes, short durations, and methodological weaknesses.

There is no substantial evidence from large, high-quality randomized controlled trials to firmly support the use of sulbutiamine or vitamin B1 for "nervous exhaustion" as a distinct clinical entity. The term itself is not well-defined in modern medicine. While sulbutiamine may have a mild stimulating effect and could benefit those with genuine thiamine deficiency, its efficacy for nervous exhaustion remains only modestly supported by scientific evidence, meriting a rating of 2 out of 5.

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