Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Bupleurum falcatum, commonly known as Chinese thoroughwax or Chai Hu, has been used for centuries in Traditional Chinese Medicine (TCM). In TCM, it is primarily known as a liver tonic and is included in herbal formulas (such as Xiao Yao San) that are traditionally used to “soothe the liver,” “regulate qi,” and relieve symptoms often associated with nervousness, such as irritability, mood swings, and mild anxiety. The traditional explanation links nervousness to liver qi stagnation, and Bupleurum is thought to help by moving and harmonizing qi.

However, direct scientific evidence supporting the use of Bupleurum falcatum specifically for nervousness or anxiety is limited. Some laboratory and animal studies have identified anti-inflammatory and neuroprotective effects of Bupleurum saponins, and a few preliminary studies suggest possible modulation of the hypothalamic-pituitary-adrenal axis, which is involved in the stress response. Nevertheless, rigorous clinical trials in humans specifically addressing nervousness or anxiety are lacking.

In summary, while Bupleurum falcatum is widely used in tradition for symptoms that overlap with nervousness, scientific validation for its efficacy in treating this condition remains weak. Its use for nervousness is justified primarily on traditional grounds, with only modest supporting evidence from modern research.

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