Evidence supporting the use of: Flavones (various)
For the health condition: Nervousness

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Flavones, a class of polyphenolic compounds found in a wide variety of plants (notably in chamomile, passionflower, and citrus fruits), have traditionally been used in herbal medicine to support conditions such as nervousness and mild anxiety. Historical use is particularly notable in herbal traditions like those of Europe and Asia, where flavone-rich plants such as chamomile (Matricaria chamomilla) and passionflower (Passiflora incarnata) were brewed into teas or extracts for their reputed calming effects. The rationale behind their use is largely based on centuries of anecdotal evidence and traditional herbal practice, rather than rigorous scientific validation.

Some preclinical studies suggest that certain flavones (such as apigenin in chamomile and vitexin in passionflower) may bind to benzodiazepine receptors in the brain, potentially exerting mild sedative or anxiolytic effects. However, human clinical data are limited and inconsistent, with few well-designed trials directly linking isolated flavones to the treatment of nervousness. Instead, most evidence relates to whole plant extracts rather than purified flavones. Therefore, while there is a strong tradition of use, the evidence supporting flavones specifically for nervousness remains limited, meriting a moderate rating.

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Products containing Flavones (various)

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