Night-Blooming Cereus (Selenicereus grandiflorus), sometimes referred to as “Queen of the Night,” has a history of use in traditional herbal medicine, particularly within homeopathy and eclectic Western herbalism. Its primary historical uses have focused on cardiovascular complaints, such as palpitations or heart-related anxiety, rather than generalized nervousness or anxiety disorders. In homeopathic practice, small doses of Night-Blooming Cereus are sometimes used for symptoms combining heart palpitations and emotional agitation, suggesting a traditional link to nervousness when it co-occurs with heart symptoms.

However, there is a lack of robust scientific studies or clinical trials validating the efficacy of Night-Blooming Cereus for the treatment of nervousness or anxiety. Most references to its use for nervousness are rooted in tradition, homeopathic materia medica, or early 20th-century eclectic medicine, rather than evidence-based medicine. The overall strength of empirical evidence is weak and anecdotal.

In summary, Night-Blooming Cereus is used for nervousness primarily in traditional and homeopathic contexts, with little to no scientific validation for this purpose. Its historical use does not appear to be widespread or well-documented outside of specific alternative medicine systems.