Evidence supporting the use of: Tetrahydropalmatine
For the health condition: Nervousness

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Tetrahydropalmatine (THP) is an alkaloid derived primarily from the plant Corydalis yanhusuo, commonly used in Traditional Chinese Medicine (TCM). Historically, THP-containing herbal preparations have been prescribed to alleviate various symptoms associated with nervous system imbalances, such as restlessness, insomnia, and mild nervousness. In TCM, the herb is believed to "calm the spirit" and promote relaxation, which has led to its traditional use for nervousness and related conditions.

Scientific studies on THP have primarily focused on its analgesic and sedative properties, with some animal and small human studies suggesting it can act as a mild tranquilizer and may have effects on dopamine pathways in the brain. However, robust clinical trials specifically evaluating its efficacy in treating or supporting nervousness in humans are lacking. The available scientific evidence is preliminary and not sufficient for strong validation, but the traditional usage is well documented in the context of TCM.

Overall, the use of tetrahydropalmatine for nervousness is justified mainly by a long-standing tradition rather than by high-quality modern clinical evidence.

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