Evidence supporting the use of: Tree Peony
For the health condition: Nervousness

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Tree Peony (Paeonia suffruticosa) has a long history of use in Traditional Chinese Medicine (TCM), where it is known as "Mu Dan Pi." It is traditionally used to "cool the blood," "clear heat," and calm agitation, which includes symptoms that might be interpreted as nervousness or anxiety in modern medical terms. Classical TCM texts sometimes recommend Tree Peony root in formulas that address emotional disturbances, restlessness, and irritability. However, the historical context does not map precisely onto the Western concept of "nervousness," but there is a traditional precedent for its use in calming the spirit (Shen) and addressing mild mental unrest.

Regarding scientific evidence, a handful of preclinical studies have investigated the effects of compounds isolated from Tree Peony (such as paeonol and paeoniflorin) on the central nervous system. Some animal studies suggest possible anxiolytic (anxiety-reducing) and neuroprotective effects, but these findings have not been extensively replicated or confirmed in high-quality human clinical trials. Therefore, while there is a traditional basis for using Tree Peony for nervousness, current scientific validation is limited and inconclusive.

In summary, Tree Peony’s use for nervousness is primarily justified by traditional use in Chinese medicine, supported by a modest body of preclinical research but lacking robust clinical evidence.

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