Evidence supporting the use of: Acetyl l-carnitine
For the health condition: Neuralgia and Neuritis
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Acetyl L-carnitine (ALC) has scientific evidence supporting its use for certain types of neuralgia and neuritis, particularly in the context of peripheral neuropathy and nerve pain associated with conditions like diabetes and chemotherapy-induced neuropathy. ALC is a naturally occurring derivative of L-carnitine that plays a role in mitochondrial energy production and has neuroprotective properties. Several clinical studies and meta-analyses indicate that ALC supplementation can reduce pain and improve nerve fiber regeneration in patients with peripheral neuropathy.
For example, randomized controlled trials have demonstrated that ALC (typically at doses of 500–3,000 mg per day) may lead to significant reductions in pain scores and improvements in nerve function, especially in diabetic and HIV-associated neuropathy. A 2005 study published in Diabetes Care and a 2010 meta-analysis in CNS Drugs both concluded that ALC is superior to placebo for improving both pain and sensory function in neuropathic patients. Its mechanism is thought to involve enhancement of nerve growth factor, mitochondrial function, and possible modulation of neurotransmitters.
However, the strength of evidence varies depending on the etiology of neuralgia or neuritis, with the best data for diabetic and chemotherapy-induced neuropathy. While ALC is generally well-tolerated, more large-scale, high-quality trials are needed to establish its efficacy across broader types of neuralgia and neuritis. Nonetheless, its use is supported by a moderate level of scientific evidence, particularly in specific neuropathic populations.
More about acetyl l-carnitine
More about Neuralgia and Neuritis
Other ingredients used for Neuralgia and Neuritis
acetyl l-carnitinebeta caryophyllene
turmeric
ginger
gotu kola
lion's mane
omega-3 fatty acids
polygala root
quail egg
reishi mushroom
vitamin B12
vitamin B6
vitamin E
cardamom
anise
lingzhi
wintergreen
arnica
7,8-Dihydroxyflavone
Aconite
Asafoetida
Agmatine
Anemone
Alpha-Lipoic Acid
Actaea spicata
Atractylone
Betony
Blue Flag
Black Hellebore
Cocarboxylase
Cnidium
Cannabidiol
Corydalis
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dimethyl sulfoxide (DMSO)
Fang-Feng
Orchid
Poppy
Other health conditions supported by acetyl l-carnitine
Aging (prevention)Alzheimer's Disease
Angina
Athletic and Exercise Aids
Attention Deficit Disorder
Autism
Body Building
Burning Feet or Hands
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Chronic Obstructive Pulmonary Disorder
Circulation (poor)
Circulation (to the brain)
Concentration (poor)
Dementia
Depression
Diabetes
Down Syndrome
Endurance (lack of)
Energy (lack of)
Exercise
Fat Metabolism (poor)
Fatigue
Fibromyalgia Syndrome
Free Radical Damage
Memory and Brain Function
Multiple Sclerosis
Muscular Dystrophy
Narcolepsy
Nerve Damage
Neuralgia and Neuritis
Numbness
Paralysis
Parkinson's Disease
Peripheral Neuropathy
Post Traumatic Stress Disorder
Stress
Strokes
Testosterone (low)
Thinking (cloudy)
Tinnitus
Wasting
Weight Loss
Products containing acetyl l-carnitine
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Integrative Therapeutics
K-PAX MitoNutrients
Klean Athlete
Klean Antioxidant ™
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Memoractiv NSF
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Memory Pro
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Memory Pro
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Mitochondria-ATP
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MotilPro
Designs For Health
NeuroRenew™
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PreTrain NRG™
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RevitalAge™ Nerve
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RevitalAge™ Ultra