Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta-caryophyllene is a natural bicyclic sesquiterpene found in various essential oils, notably clove, black pepper, and cannabis. Its use for neuralgia (nerve pain) and neuritis (nerve inflammation) is supported by emerging scientific evidence, though clinical data in humans remain limited. Beta-caryophyllene acts as a selective agonist of the cannabinoid receptor type 2 (CB2), which is primarily expressed in peripheral tissues and immune cells and is associated with anti-inflammatory and analgesic effects. Several preclinical studies in animal models have shown that beta-caryophyllene reduces neuropathic pain and neuroinflammation. For example, research published in "European Neuropsychopharmacology" (2014) and "Neuropsychopharmacology" (2012) demonstrated that beta-caryophyllene administration attenuated pain behaviors and decreased markers of inflammation in models of nerve injury. The mechanism appears to involve inhibition of pro-inflammatory cytokines and modulation of pain signaling pathways via CB2 receptor activation. However, there is a lack of robust human clinical trials specifically investigating its efficacy for neuralgia or neuritis. Most available data are limited to animal models or in vitro studies. Thus, while the scientific rationale and preclinical evidence are promising, more research—especially well-designed clinical trials—is needed to fully validate beta-caryophyllene’s therapeutic potential in these conditions.

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