Evidence supporting the use of: Vitamin B6 (pridoxal 5-phosphate)
For the health condition: Neuralgia and Neuritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6, particularly in its active form pyridoxal 5'-phosphate (PLP), has a well-established role in nerve function as a coenzyme involved in neurotransmitter synthesis and myelin formation. Deficiency in vitamin B6 can lead to neurological symptoms including peripheral neuropathy, which encompasses both neuralgia (nerve pain) and neuritis (nerve inflammation). There is scientific evidence supporting the use of vitamin B6 supplementation in cases where deficiency is present, and in such contexts, replacing the vitamin can alleviate symptoms of neuralgia and neuritis. Clinical guidelines recommend B6 supplementation for B6-deficiency neuropathies, and some small studies and case reports have demonstrated symptom improvement with correction of deficiency.

However, for neuralgia and neuritis not caused by B6 deficiency, the evidence is limited and inconsistent. Randomized controlled trials on B6 supplementation for idiopathic or other-cause peripheral neuropathies have shown mixed results, and high doses may themselves cause neurotoxicity. There is no robust evidence supporting the use of vitamin B6 as a general treatment for neuralgia or neuritis unrelated to deficiency. Most medical recommendations restrict B6 supplementation to cases of confirmed or suspected deficiency. Thus, while the scientific rationale exists for treating deficiency-induced neuropathies, broad use in all forms of neuralgia or neuritis lacks strong clinical support.

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