Aloe polysaccharides, primarily derived from Aloe vera gel, have been studied for their potential role in supporting oral surgery recovery, especially in relation to wound healing and inflammation modulation. Scientific literature suggests that Aloe vera gel exhibits anti-inflammatory, antimicrobial, and wound-healing properties, largely attributed to its polysaccharide components such as acemannan. Several in vitro and in vivo studies have demonstrated that Aloe polysaccharides can enhance fibroblast proliferation, stimulate collagen synthesis, and accelerate re-epithelialization—all processes beneficial to oral mucosal healing after surgery.

Clinical evidence, though limited, includes small randomized controlled trials and case series in which topical Aloe vera gel or mouth rinse reduced pain, promoted healing, and decreased microbial counts in patients with oral surgical wounds or aphthous ulcers. However, most studies are of low to moderate quality, with small sample sizes and variable formulations of Aloe products. Systematic reviews generally conclude that Aloe vera may be a helpful adjunct in oral wound care but call for larger, high-quality clinical trials to confirm efficacy and establish standardized dosing and application protocols.

In summary, while there is some scientific support for the use of Aloe polysaccharides in promoting oral wound healing post-surgery, the evidence base is not robust, and further research is needed to firmly establish clinical guidelines.