Evidence supporting the use of: Glycerol monolaureate
For the health condition: Oral Surgery

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycerol monolaurate (GML) is a monoglyceride with well-documented antimicrobial properties, particularly against Gram-positive bacteria and some viruses. Its use in oral surgery is supported by a growing body of scientific literature, though most evidence comes from in vitro studies, animal models, and a limited number of clinical investigations. GML functions by disrupting microbial membranes and inhibiting biofilm formation, which are significant considerations in preventing postoperative infections and promoting oral wound healing. Several studies have demonstrated that GML can reduce the growth of pathogenic bacteria commonly implicated in oral infections, such as Streptococcus mutans and Staphylococcus aureus. Additionally, its anti-inflammatory properties may contribute to improved healing outcomes after oral surgical procedures.

While these findings are promising, direct clinical evidence supporting GML’s effectiveness in oral surgery settings remains limited. Most published clinical trials focus on its use in mouthwashes or topical gels for periodontal disease or general oral hygiene, rather than as a specific adjunct for oral surgery recovery. Nevertheless, the strength of the laboratory and preclinical data has led to its inclusion in some oral care products marketed for postoperative support. In summary, there is scientific rationale and some supporting evidence for the use of GML in oral surgery, but more robust, large-scale clinical trials are needed to fully validate its efficacy and establish standardized guidelines for its application in this context.

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