Glycyrrhetinic acid, a bioactive compound derived from the hydrolysis of glycyrrhizin found in licorice root (Glycyrrhiza glabra), has been investigated for its potential benefits in oral surgery and oral health. The scientific interest in its use is based primarily on its anti-inflammatory, antimicrobial, and wound-healing properties.

Several in vitro and clinical studies have suggested that glycyrrhetinic acid can inhibit the growth of oral pathogens, including those associated with periodontal disease and postoperative infections. Its anti-inflammatory effects are attributed to the inhibition of pro-inflammatory cytokines, which may help reduce tissue swelling and discomfort following oral surgical procedures. Furthermore, glycyrrhetinic acid has shown potential in promoting epithelialization and tissue repair, possibly accelerating the healing of oral mucosal wounds.

Clinical evidence includes small randomized controlled trials and observational studies using glycyrrhetinic acid-containing oral gels or mouthwashes. These have reported benefits such as reduced gingival inflammation, decreased oral pain, and improved healing outcomes in patients undergoing tooth extractions or other oral surgeries. However, the overall quality and quantity of clinical evidence remain moderate, with limited large-scale trials and some methodological concerns.

In summary, while there is scientific rationale and some clinical data supporting the use of glycyrrhetinic acid in oral surgery, more robust, high-quality studies are needed to confirm its efficacy and establish standardized protocols.