Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactoperoxidase is an enzyme naturally present in saliva and is a key component of the oral cavity's innate defense system. Its use in oral surgery is scientifically justified, primarily due to its antimicrobial properties. Lactoperoxidase catalyzes the oxidation of thiocyanate ions (SCN-) in the presence of hydrogen peroxide (H₂O₂), producing hypothiocyanite (OSCN^-), which has broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. Several in vitro and clinical studies have demonstrated that lactoperoxidase-containing oral hygiene products can reduce oral bacterial load, inhibit plaque formation, and support the healing process by minimizing infection risk after oral surgery.

A number of randomized controlled trials and systematic reviews have shown that lactoperoxidase, especially when combined with other salivary enzymes (such as in enzyme-containing toothpastes or mouthrinses), can be beneficial in managing oral mucosal health and reducing post-surgical complications, especially in individuals with compromised salivary flow. The evidence is not as robust as that for chlorhexidine or other conventional antiseptics, and most studies focus on supportive care rather than as a primary treatment. However, its excellent safety profile and ability to enhance the mouth’s natural antibacterial defenses provide a scientific rationale for its inclusion in post-oral surgery care, particularly for patients at risk for infection or with reduced natural saliva production.

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Products containing lactoperoxidase

Metagenics Probioplex® Intensive Care Powder