Evidence supporting the use of: Lysozyme
For the health condition: Oral Surgery

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lysozyme, an enzyme with bacteriolytic properties, has a documented role in supporting oral health, particularly in the context of oral surgery. Its use is justified by scientific evidence, though the overall strength of evidence is moderate. Lysozyme is naturally present in saliva, where it contributes to the innate defense system by hydrolyzing the peptidoglycan layer of bacterial cell walls, particularly in Gram-positive bacteria. Several studies have investigated lysozyme's efficacy as an adjunct in oral surgery and dental care. For instance, lysozyme-containing lozenges or oral rinses have been shown to reduce oral microbial load, decrease inflammation, and promote healing of oral mucosa after surgical procedures. Clinical trials, mainly from Japan and parts of Europe, have reported benefits such as reduced postoperative swelling, erythema, and improved tissue repair.

The mechanism involves both antimicrobial and anti-inflammatory effects, including modulation of cytokine production and enhancement of local immune responses. However, the evidence is not uniformly robust; some studies are small or lack rigorous controls, and meta-analyses note the need for larger randomized controlled trials to confirm these benefits conclusively. Nevertheless, lysozyme remains incorporated into some oral health products intended for use after oral surgery, with regulatory approval in several countries. In summary, while lysozyme's use is supported by plausible biological mechanisms and some clinical data, the overall evidence base is moderate, warranting a rating of 3 out of 5.

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Products containing Lysozyme

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