Evidence supporting the use of: Serralysin
For the health condition: Oral Surgery

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Serralysin (also known as serratiopeptidase) is a proteolytic enzyme originally isolated from Serratia bacteria. It has been studied for its anti-inflammatory, anti-edematous, and fibrinolytic properties. In the context of oral surgery, serralysin has been investigated for its potential to reduce post-operative swelling, pain, and trismus (restricted mouth opening) following procedures such as third molar extraction. Several small-scale, mostly randomized controlled trials have compared serratiopeptidase to standard non-steroidal anti-inflammatory drugs (NSAIDs) or placebo. These studies generally report that serralysin may offer some benefit in reducing swelling and pain, though typically the effects are modest and, in many cases, not statistically superior to NSAIDs. Systematic reviews and meta-analyses suggest that while serralysin might be as effective as NSAIDs for some patients, the overall quality of evidence is low to moderate, with limitations including small sample sizes and heterogeneity in study methods. Most clinical guidelines do not recommend serralysin as a first-line agent, but it is sometimes used as an adjunct or alternative where NSAIDs are contraindicated. In summary, there is some scientific evidence supporting the use of serralysin in oral surgery, but it is not robust, and further high-quality studies are needed to clarify its role.

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