Evidence supporting the use of: Acacetin
For the health condition: Osteoporosis
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Acacetin is a natural flavonoid found in various plants and has received attention in recent years for its potential role in bone health, particularly osteoporosis. Preclinical studies—primarily in vitro and in animal models—suggest that acacetin may help prevent bone loss by modulating osteoclast and osteoblast activity. For example, research published in Phytomedicine (2018) found that acacetin could inhibit RANKL-induced osteoclast differentiation and function, which are critical processes in bone resorption associated with osteoporosis. Other animal studies have indicated that acacetin supplementation may attenuate bone loss in ovariectomized mice, a common model for postmenopausal osteoporosis.
Despite these promising results, the evidence for acacetin in osteoporosis remains preliminary. There are currently no published clinical trials examining the efficacy or safety of acacetin in humans for osteoporosis prevention or treatment. The bulk of data is limited to laboratory and animal studies, which may not fully translate to human health outcomes. Thus, while scientific interest exists and preclinical mechanisms are being elucidated, robust clinical validation is lacking. Use of acacetin for osteoporosis should be viewed as experimental and not as a substitute for established osteoporosis therapies.
Other ingredients used for Osteoporosis
7-hydroxymatairesinol (HMR)8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc