Evidence supporting the use of: Achyranthes bidentata
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Achyranthes bidentata, a traditional Chinese medicinal herb, has long been used in East Asian medicine to support bone health, including for conditions such as osteoporosis. Recent scientific research has begun exploring its effects on bone metabolism. Preclinical studies, primarily in animal models and in vitro, suggest that extracts of Achyranthes bidentata may promote osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) differentiation. For example, a 2017 study in "Molecules" showed that Achyranthes bidentata polysaccharides enhanced bone mineral density and improved bone microarchitecture in ovariectomized rats, a common model for postmenopausal osteoporosis. The presumed mechanisms include the regulation of cytokines, promotion of bone growth factors, and modulation of signaling pathways related to bone remodeling.

Despite these promising results, clinical evidence in humans is very limited. Most studies to date are preclinical, and well-designed, large-scale clinical trials are lacking. Therefore, while there is a scientific rationale and preliminary evidence for the use of Achyranthes bidentata in supporting bone health and potentially treating osteoporosis, the strength of evidence remains low, and its use cannot be considered fully validated. Further research is needed to confirm its efficacy and safety in human populations.

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