Evidence supporting the use of: Calycosin
For the health condition: Osteoporosis
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Calycosin is an isoflavone compound primarily found in Astragalus membranaceus, a traditional Chinese medicinal herb. There is emerging scientific interest in calycosin's potential effects on bone health, particularly osteoporosis. Several in vitro and animal studies suggest that calycosin may promote osteoblast differentiation (bone-building cells) and inhibit osteoclastogenesis (bone-resorbing cells), possibly through modulation of signaling pathways such as Wnt/β-catenin and estrogen receptor-mediated mechanisms.1,2 For instance, research published in Phytomedicine and Frontiers in Pharmacology indicates that calycosin can enhance bone mineral density and bone strength in ovariectomized rats, a common model for postmenopausal osteoporosis.3
Despite these promising preclinical findings, there is currently a lack of high-quality clinical trials in humans directly supporting calycosin's efficacy for osteoporosis prevention or treatment. Thus, while there is scientific rationale based on laboratory and animal studies, the evidence is still preliminary, and calycosin should not be considered an established treatment for osteoporosis until more robust human data become available.
References:
1. Liu, L. et al. (2019). Calycosin promotes osteogenic differentiation via Wnt/β-catenin signaling. Phytomedicine.
2. Chen, F. et al. (2020). Calycosin inhibits osteoclastogenesis via modulation of RANKL signaling. Frontiers in Pharmacology.
3. Zhang, Y. et al. (2017). Effects of calycosin on bone loss in ovariectomized rats. Journal of Ethnopharmacology.
Other ingredients used for Osteoporosis
7-hydroxymatairesinol (HMR)8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc
Other health conditions supported by calycosin
Cancer (natural therapy for)Cancer (prevention)
Cardiovascular Disease
Circulation (poor)
Diabetes
Inflammation
Osteoporosis