Evidence supporting the use of: Carotenoids
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Carotenoids, a class of naturally occurring pigments found in fruits and vegetables (such as beta-carotene, lycopene, lutein, and zeaxanthin), have been investigated for their potential role in supporting bone health and treating osteoporosis. Several epidemiological studies suggest an association between higher dietary intake or serum levels of carotenoids and improved bone mineral density (BMD) or reduced risk of osteoporosis, particularly in older adults. The proposed mechanisms include carotenoids’ antioxidant properties, which may protect bone cells from oxidative stress, and their potential to modulate bone remodeling by influencing osteoclast and osteoblast activity.

However, the evidence is not robust. Most data are observational, showing correlations rather than direct causation. Randomized controlled trials (RCTs) specifically evaluating carotenoid supplementation for osteoporosis prevention or treatment are scarce and often inconclusive. For example, some studies have reported that higher lycopene intake is associated with decreased bone resorption markers, but definitive effects on fracture risk or substantial improvements in BMD have not been clearly demonstrated. Current clinical guidelines do not recommend carotenoids as a primary therapy for osteoporosis, but they may play a supportive role as part of an overall diet rich in fruits and vegetables.

In summary, while there is some scientific interest and preliminary evidence suggesting carotenoids may benefit bone health, the strength of the evidence remains limited (rated 2/5). More rigorous clinical trials are needed to establish clear recommendations.

More about carotenoids
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Products containing carotenoids

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