Evidence supporting the use of: Curcumin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the primary active compound in turmeric (Curcuma longa), has been investigated for its potential role in supporting or treating osteoporosis. Osteoporosis is characterized by decreased bone mass and increased fracture risk. The scientific rationale for using curcumin in osteoporosis primarily revolves around its anti-inflammatory and antioxidant properties, as chronic inflammation and oxidative stress are known contributors to bone loss.

Several preclinical studies (in vitro and animal models) have demonstrated that curcumin can inhibit osteoclastogenesis (the formation of bone-resorbing cells), promote osteoblast differentiation (the formation of bone-building cells), and suppress inflammatory cytokines known to exacerbate bone loss. For example, animal studies have shown that curcumin supplementation can attenuate bone loss in ovariectomized rats, a common model for postmenopausal osteoporosis, likely through modulation of the RANK/RANKL/OPG pathway and reduction of oxidative damage.

However, high-quality human clinical trial data are lacking. Most evidence for curcumin’s benefit in osteoporosis is limited to laboratory and animal research, with only a few small-scale clinical studies, often with methodological limitations. Issues such as curcumin’s low bioavailability also complicate its translation to clinical use. Thus, while there is a scientific basis and some promising early data, robust human trials are needed before curcumin can be confidently recommended for osteoporosis management.

More about curcumin
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Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
Alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
Cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
Lentinula edodes mycelia
lignans
maca
magnesium
manganese
Microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
Whey protein
Zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
animal Tissue
antler
apigenin
Algas calcareas
Acacetin
astragaloside
ampelopsin
Algal protein
Algalin
Abalone
arctiin
astragalin
animal protein
bok choy
bovine protein
biochanin
bone protein
calycosin
cod liver oil
cyanidin
Chinese Ligustrum berry
DHEA
daidzein
diosgenin
Drynaria
diosmetin
epicatechin
ecdysteroids
eicosapentaenoic acid
Eucommia ulmoides
estrogen
fo-ti
formononetin
fish
flavanones
flavans
flavanols
flavones
Hyperoside
isoflavones
icariin
Kaempferol
Lycium
Lithothamnion
Legume protein
Mineral blend
Marine protein
Milk Protein
Naringenin
Neoeriocitrin
Puerarin
Phytoecdysteroid
Phaeophyceae
polysaccharides
procyanidin
proanthocyanidins
polyunsaturated fat
paeoniflorin
Phytoestrogens
polymethoxylated flavones
Rehmannia
Soy
Soy Protein
silica
Shilajit
Stilbenoid
Ursolic Acid
Vegetable Protein
Wakame
Xanthophyll