Evidence supporting the use of: Daidzein
For the health condition: Osteoporosis
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Daidzein is an isoflavone found predominantly in soy products and has been studied for its potential role in supporting bone health and treating osteoporosis, particularly in postmenopausal women. The mechanistic rationale is that daidzein can act as a phytoestrogen, binding to estrogen receptors and partially mimicking estrogen’s effects on bone metabolism. Since estrogen deficiency after menopause is a key driver of osteoporosis, compounds like daidzein have garnered scientific interest.
Several animal studies and in vitro experiments have demonstrated that daidzein can prevent bone loss, increase bone mineral density (BMD), and modulate bone turnover markers. Human studies are more limited and show mixed results. Some randomized controlled trials suggest that soy isoflavones (including daidzein) may modestly increase BMD or slow bone loss in postmenopausal women, while others show no significant benefit. Meta-analyses generally report small but statistically significant effects, though the clinical relevance is debated and the magnitude of benefit is less than that of conventional osteoporosis therapies.
Overall, the use of daidzein for osteoporosis is scientifically investigated and somewhat justified by evidence, but its effect size is modest and more research is needed to firmly establish efficacy and optimal usage. It is not considered a first-line therapy but may be used as adjunctive support, especially in populations with dietary soy intake.
Other ingredients used for Osteoporosis
7-hydroxymatairesinol (HMR)8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc
Other health conditions supported by daidzein
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Cholesterol (high)
Diabetes
Hypertension
Menopause
Osteoporosis
Triglycerides (high)