Evidence supporting the use of: Diosgenin
For the health condition: Osteoporosis
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Diosgenin is a naturally occurring steroidal saponin found primarily in plants such as wild yam (Dioscorea spp.). Its use in supporting or treating osteoporosis is based on its structural similarity to estrogen, a hormone that plays a critical role in bone health. Several in vitro and animal studies have indicated that diosgenin may have beneficial effects on bone metabolism. For example, research in ovariectomized rats (an animal model for postmenopausal osteoporosis) has shown that diosgenin can increase bone mineral density and enhance bone formation while reducing bone resorption. These effects are believed to be related to modulation of estrogen receptors and various signaling pathways involved in bone remodeling, such as the OPG/RANKL pathway.
Despite these promising preclinical findings, there is a lack of robust clinical evidence in humans to confirm its efficacy and safety in treating or preventing osteoporosis. Most human data are lacking, and diosgenin is not an approved or widely recognized treatment for osteoporosis in medical guidelines. While the scientific rationale exists and preliminary evidence appears positive, more high-quality clinical trials are needed before diosgenin can be recommended as a therapeutic agent for osteoporosis in humans.
Other ingredients used for Osteoporosis
7-hydroxymatairesinol (HMR)8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc
Other health conditions supported by diosgenin
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Diabetes
Fatty Liver Disease
Inflammation
Metabolic Syndrome
Osteoporosis
Triglycerides (high)