Evidence supporting the use of: Diosmetin
For the health condition: Osteoporosis
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Diosmetin is a flavonoid aglycone derived from diosmin, commonly found in citrus fruits. Recent preclinical studies have investigated its potential effects on osteoporosis. Laboratory (in vitro) research has shown that diosmetin can promote osteoblast differentiation and mineralization, which are critical processes for bone formation. Additionally, animal studies, particularly in ovariectomized rat models (which mimic postmenopausal osteoporosis), have demonstrated that diosmetin administration may help mitigate bone loss, improve bone microarchitecture, and increase bone mineral density. These effects are thought to occur via modulation of signaling pathways such as Wnt/β-catenin and inhibition of osteoclastogenesis, partially through anti-inflammatory and antioxidant activities. However, to date, there are no published human clinical trials evaluating diosmetin for osteoporosis prevention or treatment. The evidence remains limited to cell culture and animal models. While the mechanism of action is biologically plausible and early results are promising, the lack of high-quality human data limits the strength of the evidence supporting its use. Therefore, diosmetin’s use for osteoporosis is justified by preliminary scientific research but is not yet established as an effective or recommended therapy in humans.
Other ingredients used for Osteoporosis
7-hydroxymatairesinol (HMR)8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc
Other health conditions supported by diosmetin
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Circulation (poor)
Diabetes
Free Radical Damage
Inflammation
Osteoporosis