Evidence supporting the use of: Drynaria
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Drynaria, specifically Drynaria fortunei (commonly known as Gu Sui Bu), is a traditional Chinese medicinal herb that has historically been used for bone-related disorders, including fractures and osteoporosis. Its use is well-documented in Traditional Chinese Medicine (TCM) texts for promoting bone health and healing. In recent years, scientific interest has grown around Drynaria due to its potential effects on bone metabolism.

Preclinical studies have provided evidence supporting Drynaria's osteoprotective properties. Research in animal models of osteoporosis (such as ovariectomized rats) has demonstrated that extracts of Drynaria rhizome can increase bone mineral density, improve bone microarchitecture, and enhance markers of bone formation while reducing bone resorption. The active constituents, such as naringin and other flavonoids, are believed to stimulate osteoblast activity and suppress osteoclast differentiation, contributing to bone regeneration and maintenance.

However, while laboratory and animal studies are promising, high-quality human clinical trials are limited. Systematic reviews and meta-analyses suggest a potential benefit, but also highlight the need for more rigorous, large-scale clinical studies to confirm efficacy and safety in humans.

In summary, Drynaria is used both traditionally and has a moderate level of scientific evidence (primarily from preclinical and limited clinical data) to support its use for osteoporosis, but definitive clinical validation is still pending.

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