Evidence supporting the use of: Eucommia ulmoides
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Eucommia ulmoides, known as Du Zhong in traditional Chinese medicine (TCM), has a longstanding history of use for strengthening bones and promoting musculoskeletal health. In recent years, scientific studies have investigated its potential for supporting or treating osteoporosis. Laboratory and animal studies indicate that extracts from Eucommia ulmoides bark can promote osteoblast (bone-forming cell) proliferation and differentiation, while inhibiting osteoclast (bone-resorbing cell) activity. These effects are attributed to active compounds such as lignans, iridoids, and flavonoids, which appear to modulate pathways like the Wnt/β-catenin signaling and influence bone metabolism.

Several in vivo animal studies have reported that Eucommia ulmoides extract increases bone mineral density and improves bone microarchitecture in models of osteoporosis, such as ovariectomized rats. Some research also suggests anti-inflammatory and antioxidant effects that may contribute to bone protection. However, rigorous human clinical trials are lacking, and the current scientific evidence is primarily preclinical. While traditional use supports its application, modern validation is not yet robust. Thus, the evidence rating is moderate, with promising but not conclusive support for its use in osteoporosis.

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