Evidence supporting the use of: Fish peptides (unspecified)
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fish peptides are bioactive protein fragments derived from the enzymatic hydrolysis of fish proteins. There is emerging scientific interest in their potential role in supporting bone health, including in conditions like osteoporosis. Some in vitro and animal studies suggest that fish-derived peptides may promote osteoblast activity (cells responsible for bone formation) and inhibit osteoclast differentiation (cells responsible for bone resorption). The proposed mechanisms include enhancement of calcium absorption, antioxidant effects, modulation of inflammatory pathways, and upregulation of bone matrix proteins.

Human clinical evidence, however, remains limited. A small number of pilot studies and randomized controlled trials have investigated fish collagen peptides or fish protein hydrolysates in postmenopausal women and older adults. Some reported modest improvements in bone mineral density or markers of bone turnover. For example, a 2017 pilot study in postmenopausal women found that daily supplementation with fish collagen peptides resulted in increased bone mineral density at the spine after 6 months. However, these studies often have small sample sizes, short durations, and use different peptide preparations, making it difficult to draw firm conclusions.

In summary, while there is a plausible biological rationale and some early scientific evidence for the use of fish peptides in supporting bone health and potentially addressing osteoporosis, robust clinical evidence is currently lacking. Larger, long-term human studies are necessary to confirm their efficacy and safety for this indication.

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