Evidence supporting the use of: Flavanols
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanols, a subclass of flavonoids found in foods such as cocoa, tea, apples, and berries, have garnered interest for their potential role in supporting bone health and possibly mitigating osteoporosis. Scientific studies, primarily in vitro and animal models, suggest that flavanols may promote osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) activity, which could theoretically benefit bone density and strength. Some mechanisms proposed include antioxidant properties, modulation of signaling pathways involved in bone remodeling (e.g., RANKL/OPG), and anti-inflammatory effects.

However, direct evidence from human clinical trials is limited. A few small-scale studies have explored the impact of flavanol-rich foods (such as cocoa or green tea) on bone biomarkers or bone mineral density, with mixed results and often lacking robust, long-term data. Systematic reviews generally conclude that while preclinical evidence is promising, there is insufficient clinical evidence to recommend flavanols as a treatment or preventive measure for osteoporosis at this time. Consequently, flavanols are not considered a standard or primary therapy for osteoporosis, but ongoing research may clarify their potential adjunctive role in bone health.

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Products containing Flavanols

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