Evidence supporting the use of: Flavanols (various)
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanols, a subgroup of flavonoids found in foods such as cocoa, tea, apples, and berries, have been studied for their potential role in supporting bone health and preventing osteoporosis. Scientific evidence supporting their use is largely preclinical and observational. Flavanols possess antioxidant and anti-inflammatory properties, which may influence bone metabolism. In animal studies, flavanol-rich diets have shown improvements in bone mineral density and positive modulation of bone turnover markers. Some human observational studies suggest that higher dietary intake of flavonoids, including flavanols, is associated with greater bone density and reduced fracture risk, particularly in postmenopausal women. Proposed mechanisms include inhibition of osteoclast differentiation (reducing bone resorption) and promotion of osteoblast activity (enhancing bone formation).

However, direct interventional studies in humans are limited and often of small scale or short duration. Meta-analyses and systematic reviews note a need for larger, well-controlled clinical trials to confirm efficacy. Currently, while there is biological plausibility and supportive animal and epidemiological data, robust clinical evidence for flavanol supplementation as a treatment or preventive measure for osteoporosis is lacking. Thus, the evidence supporting flavanols for osteoporosis is promising but preliminary.

More about flavanols (various)
More about Osteoporosis

Products containing flavanols (various)

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