Evidence supporting the use of: Flavanones
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones are a subclass of flavonoids found abundantly in citrus fruits such as oranges, lemons, and grapefruits. There is emerging scientific interest in their potential role in supporting bone health and combating osteoporosis. Several preclinical studies, primarily in animal models and in vitro experiments, have demonstrated that flavanones like hesperidin and naringenin can positively influence bone metabolism. These compounds appear to promote osteoblast activity (bone-forming cells), inhibit osteoclast differentiation (bone-resorbing cells), and modulate signaling pathways related to bone remodeling, such as the RANKL/OPG pathway. Additionally, flavanones possess antioxidant and anti-inflammatory properties, which are beneficial in mitigating oxidative stress and inflammation—both of which are implicated in osteoporosis pathogenesis.

Despite these promising findings, the clinical evidence in humans is still limited. A handful of small-scale clinical trials and epidemiological studies suggest that higher dietary intake of flavanones may be associated with greater bone mineral density and reduced fracture risk. However, these studies often do not isolate the effects of flavanones specifically, and confounding dietary and lifestyle factors may play a role. Major health organizations have not yet endorsed flavanones as a treatment or adjunct for osteoporosis due to the lack of robust, large-scale randomized controlled trials in humans. In summary, while there is a scientific rationale and some supportive evidence from laboratory and early human studies, the evidence base remains preliminary.

More about Flavanones
More about Osteoporosis

Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
Alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
lentinula edodes mycelia
lignans
maca
magnesium
manganese
microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
sardines
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
tomato
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
whey protein
zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
Equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
Animal Tissue
Antler
Apigenin
Algas calcareas
Acacetin
Astragaloside
Ampelopsin
Algal protein
Algalin
Abalone
Arctiin
Astragalin
Animal protein
Bok Choy
Bovine Protein
biochanin
Bone Protein
Calycosin
Cod Liver Oil
Cyanidin
Chinese Ligustrum berry
DHEA
Daidzein
Diosgenin
Drynaria
Diosmetin
epicatechin
Ecdysteroids
Eicosapentaenoic Acid
Eucommia ulmoides
Estrogen
Fo-Ti
formononetin
Fish
Flavanones
Flavans
Flavanols
Flavones
Hyperoside
Isoflavones
icariin
Kaempferol
Lycium
Lithothamnion
Legume protein
Mineral Blend
Marine Protein
Milk Protein
Naringenin
Neoeriocitrin
Puerarin
Phytoecdysteroid
Phaeophyceae
Polysaccharides
Procyanidin
Proanthocyanidins
Polyunsaturated Fat
Paeoniflorin
Phytoestrogens
Polymethoxylated flavones
Rehmannia
Soy
Soy Protein
silica
Shilajit
Stilbenoid
Ursolic Acid
Vegetable Protein
Wakame
Xanthophyll

Products containing Flavanones

We currently have no products on Vitabase that contain this ingredient.