Evidence supporting the use of: Flavanones
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones are a subclass of flavonoids found abundantly in citrus fruits such as oranges, lemons, and grapefruits. There is emerging scientific interest in their potential role in supporting bone health and combating osteoporosis. Several preclinical studies, primarily in animal models and in vitro experiments, have demonstrated that flavanones like hesperidin and naringenin can positively influence bone metabolism. These compounds appear to promote osteoblast activity (bone-forming cells), inhibit osteoclast differentiation (bone-resorbing cells), and modulate signaling pathways related to bone remodeling, such as the RANKL/OPG pathway. Additionally, flavanones possess antioxidant and anti-inflammatory properties, which are beneficial in mitigating oxidative stress and inflammation—both of which are implicated in osteoporosis pathogenesis.

Despite these promising findings, the clinical evidence in humans is still limited. A handful of small-scale clinical trials and epidemiological studies suggest that higher dietary intake of flavanones may be associated with greater bone mineral density and reduced fracture risk. However, these studies often do not isolate the effects of flavanones specifically, and confounding dietary and lifestyle factors may play a role. Major health organizations have not yet endorsed flavanones as a treatment or adjunct for osteoporosis due to the lack of robust, large-scale randomized controlled trials in humans. In summary, while there is a scientific rationale and some supportive evidence from laboratory and early human studies, the evidence base remains preliminary.

More about flavanones
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Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc

Products containing flavanones

We currently have no products on Vitabase that contain this ingredient.