Evidence supporting the use of: Flavones
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavones are a class of polyphenolic compounds found in various fruits, vegetables, and medicinal plants. Their use in supporting or treating osteoporosis is grounded primarily in emerging scientific research rather than longstanding traditional use. Preclinical studies, including in vitro and animal models, have shown that flavones such as apigenin, luteolin, and baicalein may positively influence bone metabolism. The proposed mechanisms include stimulating osteoblast (bone-forming cell) activity, inhibiting osteoclast (bone-resorbing cell) formation, reducing oxidative stress, and modulating signaling pathways involved in bone remodeling such as the RANKL/OPG pathway. Some flavones have demonstrated the ability to enhance bone mineral density and improve bone microarchitecture in ovariectomized animal models, which are used to simulate postmenopausal osteoporosis. However, evidence in humans is limited. While some observational studies suggest that higher dietary intake of flavonoids (a broader category that includes flavones) correlates with better bone health, intervention studies specifically targeting flavone supplementation in osteoporosis patients are lacking or are of low methodological quality. No major clinical guidelines currently recommend flavone supplementation for osteoporosis treatment or prevention. Therefore, while there is a scientific rationale and promising preclinical data, the clinical evidence remains insufficient and more robust human trials are needed to confirm efficacy and safety.

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Products containing Flavones

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