Evidence supporting the use of: Flavones (various)
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavones, a subclass of flavonoids found in many fruits, vegetables, and herbs, have attracted scientific interest for their potential role in supporting bone health and the prevention or treatment of osteoporosis. Several preclinical studies (in vitro and animal models) suggest that flavones such as apigenin, luteolin, and baicalein can stimulate osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) differentiation, thereby promoting bone formation and reducing bone loss. The proposed mechanisms involve modulation of signaling pathways such as Wnt/β-catenin, RANK/RANKL/OPG, and the suppression of inflammatory cytokines that contribute to bone resorption.

Some small human studies and epidemiological data indicate that higher dietary intake of flavonoid-rich foods is associated with improved bone mineral density and reduced fracture risk, especially in postmenopausal women. However, direct clinical trials specifically isolating flavones as intervention agents for osteoporosis are limited and generally of low-to-moderate quality. Meta-analyses and reviews generally agree that while the evidence is promising, it is not yet definitive, and further well-designed human trials are needed.

In summary, the use of flavones for osteoporosis is supported by a moderate amount of scientific evidence from laboratory and animal studies, with some supportive but not conclusive human data. They are not used solely based on tradition, nor is there a complete absence of evidence.

More about Flavones (various)
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Products containing Flavones (various)

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