Evidence supporting the use of: Flavones (various)
For the health condition: Osteoporosis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavones, a subclass of flavonoids found in many fruits, vegetables, and herbs, have attracted scientific interest for their potential role in supporting bone health and the prevention or treatment of osteoporosis. Several preclinical studies (in vitro and animal models) suggest that flavones such as apigenin, luteolin, and baicalein can stimulate osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) differentiation, thereby promoting bone formation and reducing bone loss. The proposed mechanisms involve modulation of signaling pathways such as Wnt/β-catenin, RANK/RANKL/OPG, and the suppression of inflammatory cytokines that contribute to bone resorption.

Some small human studies and epidemiological data indicate that higher dietary intake of flavonoid-rich foods is associated with improved bone mineral density and reduced fracture risk, especially in postmenopausal women. However, direct clinical trials specifically isolating flavones as intervention agents for osteoporosis are limited and generally of low-to-moderate quality. Meta-analyses and reviews generally agree that while the evidence is promising, it is not yet definitive, and further well-designed human trials are needed.

In summary, the use of flavones for osteoporosis is supported by a moderate amount of scientific evidence from laboratory and animal studies, with some supportive but not conclusive human data. They are not used solely based on tradition, nor is there a complete absence of evidence.

More about Flavones (various)
More about Osteoporosis

Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
Alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
lentinula edodes mycelia
lignans
maca
magnesium
manganese
microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
sardines
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
tomato
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
whey protein
zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
Equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
Animal Tissue
Antler
Apigenin
Algas calcareas
Acacetin
Astragaloside
Ampelopsin
Algal protein
Algalin
Abalone
Arctiin
Astragalin
Animal protein
Bok Choy
Bovine Protein
biochanin
Bone Protein
Calycosin
Cod Liver Oil
Cyanidin
Chinese Ligustrum berry
DHEA
Daidzein
Diosgenin
Drynaria
Diosmetin
epicatechin
Ecdysteroids
Eicosapentaenoic Acid
Eucommia ulmoides
Estrogen
Fo-Ti
formononetin
Fish
Flavanones
Flavans
Flavanols
Flavones
Hyperoside
Isoflavones
icariin
Kaempferol
Lycium
Lithothamnion
Legume protein
Mineral Blend
Marine Protein
Milk Protein
Naringenin
Neoeriocitrin
Puerarin
Phytoecdysteroid
Phaeophyceae
Polysaccharides
Procyanidin
Proanthocyanidins
Polyunsaturated Fat
Paeoniflorin
Phytoestrogens
Polymethoxylated flavones
Rehmannia
Soy
Soy Protein
silica
Shilajit
Stilbenoid
Ursolic Acid
Vegetable Protein
Wakame
Xanthophyll

Products containing Flavones (various)

We currently have no products on Vitabase that contain this ingredient.