Evidence supporting the use of: Hyperoside
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hyperoside is a flavonoid glycoside found in various medicinal plants, including Hypericum perforatum (St. John's Wort) and Crataegus species. There is emerging, though preliminary, scientific evidence suggesting that hyperoside may have beneficial effects on bone health and osteoporosis. Several in vitro and animal studies have reported that hyperoside can enhance osteoblast differentiation and function, promote bone formation, and inhibit osteoclast-mediated bone resorption. For example, a study published in Phytomedicine (2012) found that hyperoside could stimulate osteogenic differentiation of bone marrow stromal cells via the BMP and Wnt/β-catenin pathways. Other animal studies have shown that hyperoside supplementation can reduce bone loss in ovariectomized rats, a common model for postmenopausal osteoporosis, by modulating oxidative stress and inflammatory mediators.

However, there is a lack of robust clinical evidence in humans. To date, no large-scale randomized controlled trials have evaluated the efficacy or safety of hyperoside for osteoporosis in humans. Thus, while laboratory studies provide some scientific rationale and support a potential mechanism of action, the current level of evidence remains preclinical. Further clinical research is required to determine whether these effects translate to meaningful benefits in human osteoporosis prevention or treatment.

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Products containing Hyperoside

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