Evidence supporting the use of: Isoflavones
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones, primarily derived from soy and other legumes, are phytoestrogens—plant compounds with estrogen-like activity. Their use in osteoporosis is supported by a moderate level of scientific evidence, largely based on their potential to mimic estrogen’s bone-protective effects, which is particularly relevant in postmenopausal women experiencing decreased estrogen levels and subsequent increased bone resorption. Several randomized controlled trials and meta-analyses have examined the impact of isoflavone supplementation on bone mineral density (BMD) and bone turnover markers.

A 2017 meta-analysis (Zhao et al., 2017, Medicine) found that isoflavone supplementation could result in a modest increase in BMD at the lumbar spine and femoral neck in postmenopausal women, though the effect size was relatively small. Similarly, a 2019 systematic review (Wei et al., Journal of Bone and Mineral Metabolism) reported that soy isoflavones may slow bone loss, but the clinical significance and long-term benefits remain uncertain due to heterogeneity among studies, variations in dosage, and differences in baseline dietary intake.

Overall, while there is some scientific validation for the use of isoflavones in supporting bone health and potentially preventing osteoporosis, the evidence is not robust enough for isoflavones to be considered a standalone therapy. Most guidelines recommend them as an adjunct to, not a replacement for, established osteoporosis treatments. Further large-scale, long-term trials are needed to clarify their efficacy and safety.

More about Isoflavones
More about Osteoporosis

Products containing Isoflavones

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